Dynamic structures in DNA damage responses & cancer
نویسندگان
چکیده
منابع مشابه
DAMAGE IDENTIFICATION IN STRUCTURES USING TIME DOMAIN RESPONSES BASED ON DIFFERENTIAL EVOLUTION ALGORITHM
An effective method utilizing the differential evolution algorithm (DEA) as an optimisation solver is suggested here to detect the location and extent of single and multiple damages in structural systems using time domain response method. Changes in acceleration response of structure are considered as a criterion for damage occurrence. The acceleration of structures is obtained using Newmark me...
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For many years, the study of the regulation of the SOS network was complicated by both the complexities of the responses and the interrelationships of the key regulatory elements. However, recently the application of powerful genetic and molecular biological techniques has allowed us to gain a detailed picture of the regulation of this complex network. The network is now known to consist of mor...
متن کاملRadiation-induced DNA damage responses.
The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage. Such mechanisms include pathways of DNA rep...
متن کاملCellular responses to DNA damage.
Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging agents. These agents can either be exogenous or formed within cells. Environmental DNA-damaging agents include UV light and ionizing radiation, as well as a variety of chemicals encountered in foodstuffs, or as air- and water-borne agents. Endogenous damaging agents include methylating species and the rea...
متن کاملDNA damage responses in mammalian oocytes.
DNA damage acquired during meiosis can lead to infertility and miscarriage. Hence, it should be important for an oocyte to be able to detect and respond to such events in order to make a healthy egg. Here, the strategies taken by oocytes during their stages of growth to respond to DNA damaging events are reviewed. In particular, recent evidence of a novel pathway in fully grown oocytes helps pr...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 2015
ISSN: 0079-6107
DOI: 10.1016/j.pbiomolbio.2015.04.003